For most cancer centers, cell processing is an integral part of the oncology program. This technology is crucial to the success of a patient's treatment plan. The lab started as a support for hematopoietic stem cell transplantation programs, adapted transfusion equipment to separate red blood cells from stem cells, and processed the stem cells into plasma and other components. With the success of cellular cancer immunotherapies, the role of the cell processing laboratory has increased. HSC transplantation is a common treatment for many diseases, and it is an excellent complement to CAR T-cell therapy.
The
facility is equipped with 12 ISO 7 clean rooms and has access to an additional
three. These rooms operate at positive pressure relative to an external
corridor and have a low air change rate of 20-40 hPa. Each room is outfitted
with a sterile work surface and a 6" biological safety cabinet. Other
equipment in the clean rooms includes a refrigerator, multiple HEPA-filtered
incubators, a PC with barcode scanning, and cell separation and counting.
The
global cell
processing market report also includes a comprehensive business
analysis of the current state of the industry, which examines innovative
business growth strategies and describes critical factors such as leading
manufacturers, production value, key regions, and growth rate.
The
Sefia S-2000 cell processing system is a multifunctional instrument that allows
an operator to automate various steps of the cell therapy manufacturing process.
It has dedicated software and disposable kits that allow operators to automate
the individual steps. In addition, the S-2000's high capacity and
temperature-controlled environment make it the perfect choice for larger
companies or biopharmaceutical research labs. In addition, it has a weight
sensor and can process up to 10 L of cellular product.
Achieving
high cell yields is essential for the industrialized mass production of
adherent-dependent cultures. To achieve high cell recovery, manufacturers prefer
optimized downstream solutions. They also emphasize the use of animal-origin
raw materials. With all of this in mind, supply chain management is essential
to ensure that samples reach the manufacturing facility or hospital safely.
Additionally, cryopreservation, when combined with high-quality reagents,
improves the effectiveness of the process.