Tylosin a synthetic bactericidal agent used in veterinary medicine is a bacteriostatic feed additive and macrolide antibiotic. It has both a broad spectrum of action against gram-positive bacteria and a restricted range of action against gram-negative bacteria. It is normally found as a thin fermentation product of the Streptomyces family. It has been used for decades in the pharmaceuticals industry for the treatment of gram-positive and Gram-negative infections in animals including humans.
Tylosin has been used to cure various gram-negative infections in cattle and sheep. Rhesus deadly is one of the antibiotic-resistant organisms causing severe illness in human beings. Tylosin has been used to cure this Gram-negative bacterium by preventing the release of Vembanavir (ATP), which is an inhibitor of Streptococcus viridans. Tylosin has also been used to treat R. streptococcus infection of the eyes (R.A. streptolyticus), throat (R.S. streptococcus ophthalmicus), tonsillitis, and persistent ear infection (Tolliculitis Erythematus).
In the past few years, Tylosin has found its use in the treatment of arthritis and rheumatism. Oral administration of Tylosin has also been found effective in the treatment of acne, chronic fatigue syndrome, cystic fibrosis, diverticulitis, edema, leukemia, liver disease, kidney disease, pneumonia, Psoriatic Arthritis, thyroid dysfunction, and xerostomia. In certain cases, oral antibiotics are quite ineffective against a Gram-negative bacterium like Mycoplasma genitalium. Tylosin acts against these bacteria by reducing the level of proton pumps and sulfate esters. To increase the amount of sulfur esterase, Tylosin has been used to increase the production of the neurotransmitter serotonin. Tylosin can also be used to increase the levels of at least two neurotransmitters, noradrenaline, and dopamine, in patients with Alzheimer's disease.