Blocking Phosphodiesterase-4 Enzyme Offers Potential in Treatment of Dry Mouth and Cystic Fibrosis

 Cystic Fibrosis (CF) is a life-threatening chronic pulmonary disorder that results from the failure of the respiratory tract's organs. It is the most common autosomal recessive genetic disorder among Caucasians, but it is quite rare in Southeast Asia, including Japan. CF is inherited by most babies after birth, although it is possible for some to be born with the disorder. It affects the cells which produce sweat, mucus, and digestive juices in the airways.

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Cystic fibrosis signs and symptoms may go unnoticed in early childhood or adolescence when they are more likely to disappear on their own. In most cases, symptoms only become apparent in adulthood or later in life when medical treatments have been sought. Doctors often diagnose cystic fibrosis in childhood or adolescence, because there are few or no outward signs. Cystic fibrosis is one of several similar disorders that share many symptoms, including chronic coughs that produce a very little amount of clear mucus, unusual weight loss, dehydration, and liver abnormalities. CF affects the tubes that carry digestive enzymes from your pancreas to your small intestine. Digestive enzymes are produced in your pancreas and liver. They help break down and process food and other substances into usable energy for your body... Read more

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